Fresh analysis indicates that people who come off popular GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who stop conventional diet and exercise programs.
Research printed in a major medical journal demonstrates that while obese people often shed a large proportion of their total mass while undergoing treatment, the mass comes back at an estimated rate of nearly a kilo each month after stopping.
"People buying these medications should be informed of the risk of quick rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
That rate of regain suggests a return to starting weight in about 18 months.
Weighing Approaches
The study, which reviewed dozens of studies involving thousands of patients, compared the effects of these new drugs with older methods.
Scientists note that individuals who shed pounds through dieting generally have a less rapid weight regain—around 100 grams monthly—post-intervention.
The Reason for the Quick Regain
Nutrition scientists suggest the mechanism of the injections is key to understanding the accelerated rebound.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which controls appetite.
"Sustained high doses of GLP-1 levels several times higher than the body's typical production might result in the system to produce less of its own natural hormone, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this medication leads to hunger is no longer kept in check, making excessive eating a significant risk."
A Chronic Issue?
Health authorities advise the jabs for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
Many experts contend that, due to the significant potential of relapse, the therapy should be considered long-term.
This view is supported by pharmaceutical companies, who state that the results "highlight the persistent nature of excess weight," comparing it to managing conditions like hypertension.
User Testimonies
Users who have come off the medication explain a powerful return of appetite.
"It was like a switch flipping and I was suddenly extremely hungry," recalled an individual.
This challenge is compounded if individuals have not developed permanent dietary or behavioural changes during therapy.
Widespread Interest
Figures suggest that millions of people in the UK have used weight-loss jabs in the last 12 months, with interest continuing to grow.
- Adoption is greater among females than males.
- The 40s and 50s demographic shows the greatest usage rates.
- Many access the medications through private healthcare rather than the NHS.
In conclusion, clinicians emphasize that while the jabs are powerful agents for shedding pounds, they are not a standalone solution and long-term success hinges on integrated lifestyle management.
